Endothelin-2, human
CAS No. 123562-20-9
Endothelin-2, human ( Endothelin-2 (human, canine); Human endothelin-2 )
Catalog No. M29873 CAS No. 123562-20-9
Endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 642 | In Stock |
|
10MG | 888 | In Stock |
|
25MG | 1332 | In Stock |
|
50MG | 1782 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
Biological Information
-
Product NameEndothelin-2, human
-
NoteResearch use only, not for human use.
-
Brief DescriptionEndogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.
-
DescriptionEndogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.(In Vitro):At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM). Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.(In Vivo):Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr.
-
SynonymsEndothelin-2 (human, canine); Human endothelin-2
-
PathwayOthers
-
TargetOther Targets
-
RecptorET-RA, ET-RB
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number123562-20-9
-
Formula Weight2546.9
-
Molecular FormulaC115H160N26O32S4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400.
molnova catalog
related products
-
Suspenoidside B
Suspenoidside B possesses strong hepatoprotective activities against the damage in HepG2 cell.
-
WR-99210
WR-99210 is a potent inhibitor of?Plasmodium falciparum?dihydrofolate reductase (pfDHFR), which is a major malarial drug target.
-
Oroxin A
Oroxin A has antitussive and expectorant effects.