Endothelin-2, human
CAS No. 123562-20-9
Endothelin-2, human ( Endothelin-2 (human, canine); Human endothelin-2 )
Catalog No. M29873 CAS No. 123562-20-9
Endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 642 | In Stock |
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10MG | 888 | In Stock |
|
25MG | 1332 | In Stock |
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50MG | 1782 | In Stock |
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100MG | Get Quote | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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Biological Information
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Product NameEndothelin-2, human
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NoteResearch use only, not for human use.
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Brief DescriptionEndogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.
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DescriptionEndogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.(In Vitro):At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM). Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.(In Vivo):Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr.
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SynonymsEndothelin-2 (human, canine); Human endothelin-2
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PathwayOthers
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TargetOther Targets
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RecptorET-RA, ET-RB
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Research Area——
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Indication——
Chemical Information
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CAS Number123562-20-9
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Formula Weight2546.9
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Molecular FormulaC115H160N26O32S4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400.
molnova catalog
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